Testosterone to Estradiol Ratio Calculator

Created by Małgorzata Koperska, MD
Reviewed by Bogna Szyk
Last updated: Feb 15, 2022

The calculation of testosterone to estradiol ratio, also known as T/E2, is a parameter linked to a whole spectrum of male health aspects, primarily associated with sexual functions. The values needed for the estimation are free testosterone (T) and estradiol (E2) concentrations. The calculator can also be used for converting estradiol and testosterone units of measurement.

How is testosterone to estradiol ratio calculated?

The formula itself is very simple:

ratio = testosterone / estradiol

The tricky part is that before the calculation of testosterone to estradiol ratio, both hormone concentrations need to be expressed in the same units, and they're generally presented in different ways: testosterone in ng/dL, and estradiol in pg/mL.

There's no fixed range for the ratio value. It's important that testosterone (10-35 nmol/L or 300-1000 ng/dL) and estradiol levels (50-200 pmol/L or 14-55 pg/mL) are within normal ranges. There is a very interesting article by drs. Moskowic, Eisenberg, and Lipschultz on the topic of T/E2 ratio fluctuations.

What unit is testosterone measured in?

The most frequently used testosterone unit of measurement is ng/dL (nanogram per deciliter), and the international standard is nmol/L (nanomole per liter). The conversion of its concentration is calculated by using this formula:

1 nmol/L = 1000 pmol/L = 28.85 ng/dL


1 ng/dL = 0.03466 nmol/L = 34.66 pmol/L

You could expect the conversion of estradiol units to be conducted in the same way. However, the concentration of every substance is calculated differently. For estradiol, it's done this way:

1 pmol/L = 0.2724 pg/mL


1 pg/mL = 3.6713 pmol/L

Check out our other calculators to see how progesterone, cholesterol, and glucose units are converted.

What is testosterone to estradiol ratio?

According to scientific research, T/E2 ratio is a parameter linked to various aspects of male health:

  • Male coronary heart disease development:
    Imbalance of testosterone/estradiol promotes male CHD development.
  • Development of ameliorate depressive symptoms:
    Neuroprotective effect of a physiological ratio of testosterone and estradiol on corticosterone-induced apoptosis in PC12 cells via Traf6/TAK1 pathway
  • Atherosclerosis development:
    Synergistic Effect of a Physiological Ratio of Estradiol and Testosterone in the Treatment of Early-stage Atherosclerosis
  • Infertility treatment prognosis:
    Role of testosterone/estradiol ratio in predicting the efficacy of tamoxifen citrate treatment in idiopathic oligoasthenoteratozoospermic men
  • Prediction of low libido and erectile dysfunctions:
    Calculated Free T and T:E Ratio but not Total Testosterone and Estradiol Predict Low Libido

Check out other ratio calculators, such as cholesterol ratio calculator.

Małgorzata Koperska, MD
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