Testosterone to Estradiol Ratio Calculator

Created by Małgorzata Koperska, MD
Reviewed by Bogna Szyk and Aleksandra Zając, MD
Based on research by
Moskovic DJ, Eisenberg ML, Lipshultz LI Seasonal Fluctuations in Testosterone-Estrogen Ratio in Men From the Southwest United States Journal of Andrology (Jan 2013)See 5 more sources
Hong-Yun Zheng, Yan Li, Wen Dai, Chuan-Dong Wei, Kai-Sheng Sun, Yong-Qing Tong Imbalance of testosterone/estradiol promotes male CHD development Bio-medical Materials and Engeneering (2012)Rui Peng, Wen Dai, Yan Li Neuroprotective effect of a physiological ratio of testosterone and estradiol on corticosterone-induced apoptosis in PC12 cells via Traf6/TAK1 pathway Toxicology In Vitro (Aug 2018)Wen Dai, Wang Ming, Yan Li, Hong-Yun Zheng, Chuan-Dong Wei, Zhao Rui, Cui Yan Synergistic Effect of a Physiological Ratio of Estradiol and Testosterone in the Treatment of Early-stage Atherosclerosis Archives of medical research (Nov 2015)Murat Cakan, Mustafa Aldemir, Murat Topcuoglu, Uğur Altuğ Role of testosterone/estradiol ratio in predicting the efficacy of tamoxifen citrate treatment in idiopathic oligoasthenoteratozoospermic men Urologia Internationalis (Dec 2009)Hanan Goldberg, MD Calculated Free T and T:E Ratio but not Total Testosterone and Estradiol Predict Low Libido American Urological Association (May 2017)
Last updated: Jun 05, 2023

The calculation of testosterone to estradiol ratio, also known as T/E2, is a parameter linked to a whole spectrum of male health aspects, primarily associated with sexual functions. The values needed for the estimation are free testosterone (T) and estradiol (E2) concentrations. You can also use the calculator to convert estradiol and testosterone measurement units.

We try our best to make our Omni Calculators as precise and reliable as possible. However, this tool can never replace a professional doctor's assessment. If any health condition bothers you, consult a physician.

How is testosterone to estradiol ratio calculated?

The formula itself is straightforward:

ratio = testosterone / estradiol

The tricky part is that before calculating the testosterone to estradiol ratio, both hormone concentrations need to be expressed in the same units. They're generally presented in different ways: testosterone in ng/dL and estradiol in pg/mL.

There's no fixed range for the ratio value. It's important that testosterone (10-35 nmol/L or 300-1000 ng/dL) and estradiol levels (50-200 pmol/L or 14-55 pg/mL) are within normal ranges.

There is an engaging article by Drs. Moskovic, Eisenberg, and Lipschultz on the topic of T/E2 ratio fluctuations (see the first source at the top of this page).

What unit is testosterone measured in?

The most frequently used testosterone unit of measurement is ng/dL (nanogram per deciliter), and the international standard is nmol/L (nanomole per liter).

The conversion of its concentration is calculated by using these formulae:

1 nmol/L = 1000 pmol/L = 28.85 ng/dL


1 ng/dL = 0.03466 nmol/L = 34.66 pmol/L

You could expect the conversion of estradiol units to be conducted in the same way. However, the concentration of every substance is calculated differently. For estradiol, you do it this way:

1 pmol/L = 0.2724 pg/mL


1 pg/mL = 3.6713 pmol/L

Check out the following other calculators to see how progesterone, cholesterol, and glucose units are converted:

What is testosterone to estradiol ratio?

According to scientific research, the T/E2 ratio is a parameter linked to various aspects of male health:

  • Male coronary heart disease development.

  • Development of ameliorate depressive symptoms.

  • Atherosclerosis development.

  • Infertility treatment prognosis.

  • Prediction of low libido and erectile dysfunctions.

Check out other ratio calculators, such as cholesterol ratio calculator.


What is a good testosterone to estradiol ratio?

There are no fixed values for the T/E2 ratio to be considered healthy. It's considered good as long as the individual hormone levels are within normal ranges:

  • Testosterone (T): 300-1000 ng/dL (10-35 nmol/L); and
  • Estradiol (E2): 14-55 pg/mL (50-200 pmol/L).

How do I calculate the testosterone to estradiol ratio?

To calculate the T/E2 ratio:

  1. Determine the concentrations of testosterone (T) and estradiol (E2).
  2. Make sure that they're expressed in the same units.
    • Remember that the conversion of concentration for each substance is different!
  3. Divide the value for testosterone by the one measured for estradiol - this is the testosterone to estradiol ratio.

What is the T/E2 ratio for 60 ng/dL of testosterone and 29 pg/mL of estradiol?

The testosterone to estradiol ratio is 19.53.
To see that this is the case, we convert both concentrations so they have consistent units:
testosterone/estradiol = (60 × 34.66 pmol/L) / (29 × 3.6713 pmol/L) = 2079.7 / 106.47 = 19.53.

Can estradiol be converted into testosterone?

No. Testosterone can be converted into estradiol through the aromatase enzyme if it doesn't bind to any androgen receptor - typically, this happens to a small fraction of it. However, this does not work the other way around.

Małgorzata Koperska, MD
Testosterone (T)
Estradiol (E2)
Ratio (T/E2)
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