NAFLD Fibrosis Score Calculator

By Joanna Michałowska, PhD candidate
Last updated: Jul 06, 2020

This NAFLD fibrosis score calculator identifies liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). It estimates the progression of scarring in the liver based on a few laboratory tests, can be used to predict the risk of end-stage liver disease and can evaluate the progression or stabilization of said liver disease. Read the article below to find out more about NAFLD, the NAFLD score formula and the NAFLD score interpretation.

If you are interested in other calculators related to the liver disease, check the MELD (Model for End-Stage Liver Disease), FIB-4, and APRI (AST to Platelet Ratio Index) calculators.

We try our best to make our Omni Calculators as precise and reliable as possible. However, this tool can never replace a professional doctor's assessment.

Non-alcoholic fatty liver disease (NAFLD)

Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide. It is assumed that this disorder is present in approximately 25% of the world's population. NAFLD is associated with an excessive fat build-up in the liver without another clear cause, e.g. alcohol use. Usually it does not give noticeable signs and is often diagnosed during routine health checks. In some cases, NAFLD can cause symptoms related to liver dysfunction, which include fatigue, malaise, or mild yellow discoloration of the skin. NAFLD may eventually lead to complications such as cirrhosis, liver cancer, liver failure, or cardiovascular disease.

The risk factors of NAFLD include:

  • being overweight or obese;
  • diabetes;
  • metabolic syndrome;
  • diet rich in fructose; and
  • older age.

NAFLD fibrosis score

Liver biopsy is considered to be the gold standard for the diagnosis and assessment of liver fibrosis, however this method has several limitations, which include high cost and invasiveness. Therefore, a noninvasive indicator of liver fibrosis in patients with NAFLD has been developed - the NAFLD fibrosis score.

It consists of six following components:

  • age;
  • presence of hyperglycemia;
  • body mass index;
  • platelet count;
  • albumin level; and
  • aspartate aminotransferase and alanine aminotransferase (AST/ALT) ratio.

The NAFLD fibrosis score was found to independently identify NAFLD patients with and without advanced fibrosis at the initial NAFLD diagnosis. Moreover, several studies validated it and confirmed that it has acceptable sensitivity, specificity, and positive and negative predictive values for advanced liver fibrosis.

NAFLD score formula

NAFLD fibrosis score calculator uses the following formula to compute the NAFLD fibrosis score:

NFS = -1.675 + (0.037 * age) + (0.094 * BMI) + (1.13 * hyperglycemia) + (0.99 * AST/ALT ratio) - (0.013 * platelet count) - (0.66 * albumin)

where:

NFS - NAFLD fibrosis score;

age - age expressed in years;

BMI - Body Mass Index expressed in kg/m² (the NAFLD fibrosis score calculator calculates it for you);

hyperglycemia - presence of impaired fasting glucose or diabetes (yes = 1, no = 0);

AST/ALT ratio - AST and ALT levels expressed in IU/L (the NAFLD fibrosis score calculator calculates AST/ALT ratio for you);

platelet count - platelet count expressed in 10⁹/L; and

albumin - albumin level expressed in g/dL (the NAFLD fibrosis score calculator can also convert it from g/L).

NAFLD fibrosis score range

The following NAFLD fibrosis score range is used to identify liver fibrosis:

NAFLD fibrosis score
Interpretation
Less than -1.455
Low probability of fibrosis
From -1.455 to 0.676
Intermediate score
More than 0.676
High probability of fibrosis at baseline

A score lower than -1.455 can exclude advanced fibrosis with a high accuracy, whereas score higher than 0.676 is highly indicative of advanced fibrosis. Applying this model may help avoid unnecessary liver biopsy.

Joanna Michałowska, PhD candidate
Personal details
Age
years
Height
ft
in
Weight
lb
IFG or diabetes?
No
Laboratory test results
AST level
IU/L
ALT level
IU/L
Platelet count
⋅10⁹/L
Albumin level
g/dL
Results
NAFLD fibrosis score
People also viewed…

Benadryl

Use the benadryl dosage calculator to check how much Benadryl you should take yourself or give to your little one.

Car vs. Bike

Everyone knows that biking is awesome, but only this Car vs. Bike Calculator turns biking hours into trees! 🌳

Coffee kick

A long night of studying? Or maybe you're on a deadline? The coffee kick calculator will tell you when and how much caffeine you need to stay alert after not sleeping enough 😀☕ Check out the graph below!

Drops per minute

The drops per minute calculator is a simple tool for calculating drop factor, drops per minute, or volume needed for a given intravenous therapy time.
main background