NAFLD Fibrosis Score Calculator

Created by Joanna Michałowska, PhD candidate and Aleksandra Zając, MD
Reviewed by Bogna Szyk and Jack Bowater
Based on research by
Paul Angulo, Jason M Hui, Giulio Marchesini, Ellisabetta Bugianesi, Jacob George, Geoffrey C Farrell, Felicity Enders, Sushma Saksena, Alastair D Burt, John P Bida, Keith Lindor, Schuyler O Sanderson, Marco Lenzi, Leon A Adams, James Kench, Terry M Therneau, Christopher P Day The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD Hepatology (April 2007)See 2 more sources
Sombat Treeprasertsuk, Einar Björnsson, Felicity Enders, Sompongse Suwanwalaikorn, and Keith D Lindor NAFLD fibrosis score: A prognostic predictor for mortality and liver complications among NAFLD patients The World Journal of Gastroenterology (Feb 2013)Thomas Marjot, Ahmad Moolla, Jeremy F Cobbold, Leanne Hodson, Jeremy W Tomlinson Nonalcoholic Fatty Liver Disease in Adults: Current Concepts in Etiology, Outcomes, and Management Endocrine Reviews (Feb 2020)
Last updated: Jun 05, 2023


This NAFLD fibrosis score calculator identifies liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). It estimates the progression of scarring in the liver based on a few laboratory tests, can be used to predict the risk of end-stage liver disease and can evaluate the progression or stabilization of said liver disease. Read the article below to find out more about NAFLD, the NAFLD score formula and the NAFLD score interpretation.

If you are interested in other calculators related to the liver disease, check the MELD calculator (Model for End-Stage Liver Disease), FIB-4 calculator, and APRI calculator (AST to Platelet Ratio Index).

We try our best to make our Omni Calculators as precise and reliable as possible. However, this tool can never replace a professional doctor's assessment.

Non-alcoholic fatty liver disease (NAFLD)

Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide. It is assumed that this disorder is present in approximately 25% of the world's population. NAFLD is associated with an excessive fat build-up in the liver without another clear cause, e.g. alcohol use. Usually it does not give noticeable signs and is often diagnosed during routine health checks. In some cases, NAFLD can cause symptoms related to liver dysfunction, which include fatigue, malaise, or mild yellow discoloration of the skin. NAFLD may eventually lead to complications such as cirrhosis, liver cancer, liver failure, or cardiovascular disease.

The risk factors of NAFLD include:

  • Being overweight or obese;
  • Diabetes;
  • Metabolic syndrome;
  • Diet rich in fructose; and
  • Older age.

NAFLD fibrosis score

Liver biopsy is considered to be the gold standard for the diagnosis and assessment of liver fibrosis, however this method has several limitations, which include high cost and invasiveness. Therefore, a noninvasive indicator of liver fibrosis in patients with NAFLD has been developed - the NAFLD fibrosis score.

It consists of six following components:

The NAFLD fibrosis score was found to independently identify NAFLD patients with and without advanced fibrosis at the initial NAFLD diagnosis. Moreover, several studies validated it and confirmed that it has acceptable sensitivity, specificity, and positive and negative predictive values for advanced liver fibrosis.

NAFLD score formula

NAFLD fibrosis score calculator uses the following formula to compute the NAFLD fibrosis score:

NFS = -1.675 + (0.037 × age) + (0.094 × BMI) + (1.13 × hyperglycemia) + (0.99 × AST/ALT ratio) - (0.013 × platelet count) - (0.66 × albumin)

where:

NFS - NAFLD fibrosis score;

age - age expressed in years;

BMI - Body Mass Index expressed in kg/m² (the NAFLD fibrosis score calculator calculates it for you);

hyperglycemia - presence of impaired fasting glucose or diabetes (yes = 1, no = 0);

AST/ALT ratio - AST and ALT levels expressed in IU/L (the NAFLD fibrosis score calculator calculates AST/ALT ratio for you);

platelet count - platelet count expressed in 10⁹/L; and

albumin - albumin level expressed in g/dL (the NAFLD fibrosis score calculator can also convert it from g/L).

NAFLD fibrosis score range

The following NAFLD fibrosis score range is used to identify liver fibrosis:

NAFLD fibrosis score

Interpretation

Less than -1.455

Low probability of fibrosis

From -1.455 to 0.676

Intermediate score

More than 0.676

High probability of fibrosis at baseline

A score lower than -1.455 can exclude advanced fibrosis with a high accuracy, whereas score higher than 0.676 is highly indicative of advanced fibrosis. Applying this model may help avoid unnecessary liver biopsy.

Joanna Michałowska, PhD candidate and Aleksandra Zając, MD
Personal details
Age
years
Height
ft
in
Weight
lb
IFG or diabetes?
No
Laboratory test results
AST level
IU/L
ALT level
IU/L
Platelet count
× 10⁹/L
Albumin level
g/dL
Results
NAFLD fibrosis score
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