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Lille Score Calculator

Created by Łucja Zaborowska, MD, PhD candidate
Reviewed by Steven Wooding
Last updated: Jun 05, 2023


The Lille score calculator gives you an estimate of the 6-month survival rate in patients with a diagnosis of alcoholic hepatitis that already take steroids to improve hepatic functions.

Our handy tool offers you a wide range of clinical units to use, while the article below will furnish you with necessary theory that stands behind all the calculations. Read on to find out more about alcoholic hepatitis and the Lille score for this liver disease! 📚

Alcoholic hepatitis

Alcohol hepatitis is the inflammation of the liver cells caused by drinking too much alcohol. As we all know, the liver is an organ responsible for processing alcohol. However, if its intake is too excessive and lasts for too long, the tissue's irreversible changes start to appear.

This disease can slowly develop over the years, or it may cause a sudden loss of liver function that results in quick death.

If the disease's development is slow, the process eventually leads to a cirrhosis - irreversible damage of the liver, where the only treatment possible is the liver transplant.

However, you can prevent all these after-effects by simply stopping drinking. The liver is an organ with exceptional self-regeneration skills!

Why do we need the alcoholic hepatitis score?

All the hepatitis scores, including the well-known Child-Pugh calculator, serve as tools for predicting mortality, survival, or response to a given treatment. They're necessary tools that help physicians make the right clinical decisions and maximize the possibility of recovery.

Alcohol remains one of the main reasons for liver impairment in developing and developed countries; the tools that facilitate estimations of its excessive intake include:

  • Alcohol units
  • Audit test calculator - the "am I an alcoholic?" screen
  • Audit-C screen - shorter version of the Audit test

How to use the Lille score calculator?

The Lille score alcoholic hepatitis calculator should be used for patients on a steroid therapy to evaluate their chances of improvement and reconsider other treatment options.

This tool requires a total of 6 steps.

  1. 5 of these values you will need to gather on admission day - remember always to choose the appropriate unit.

    • PT, given in seconds.

      Some laboratories only include the INR*! Read more about the difference between these two variables in the INR calculator.

    • Creatinine as a measure of renal insufficiency.

💡 In clinical practice we can measure the renal function by using the glomerular filtration rate - GFR or the albumin creatinine ratio.

  • Albumin - a protein found in blood plasma, produced by the liver. In the case of liver impairment, its amount decreases.

    We may also measure serum-ascites albumin gradient SAAG to determine the origin of the ascites (collection of fluid in the abdomen).

    • Bilirubin - a substance produced by the liver from the used-up erythrocytes
  1. 1 variable gathered on the 7th day after admission, at the end of the steroid treatment:

    • Bilirubin.
  2. Since you complete all of the steps enumerated above, you're good to go. 🎉 Input all the data into the appropriate fields of the calculator.

Our Lillie score tool will tell you your patient's predicted survival within the 6-month period of follow-up.

Is everything clear? 🤭 Maybe it's time to go one step further, and discover the Maddrey's Discriminant function calculator for prognosis of alcoholic hepatitis; let it be a beginning of an interesting journey!

How to calculate the Lille model/score?

Lille model calculations are not the easiest ones; the use of the alcoholic liver disease calculators is highly recommended.

However, if you'd like to try it yourself, we'll help you all along the way!

  1. You'll need to gather all the clinical data and convert it into proper units:

    • Age in years, PT in seconds,

    • Albumin in grams per liter (g/L)

      1 g/dL = 10 g/L

    • Bilirubin in micromole per liter (µmol/L)

      1 mg/dL = 17.1 µmol/L = 18.73 mg%

    • Creatinine in micromole per liter (µmol/L)

      1 mg/dL = 88.4 µmol/L

  2. Estimate the renal insufficiency value

    • If creatinine > 1.3 mg/dL (115 µmol/L), the renal insufficiency takes value of 1.
    • If creatinine ≤1.3 mg/dL (115 µmol/L), the renal insufficiency takes value of 0.
  3. Use the hepatitis score equation

    Our Lille score calculator uses the two-steps formula:

    a) Computing the R variable:

    R = 3.19 – (0.101 × Age) + (0.147 × Albumin) + (0.0165 × (Bilirubin day 7 - Bilirubin day 0)) - (0.206 × Renal insufficiency) - (0.0065 × Bilirubin day 0) - (0.0096 × PT)

    b) Computing the actual Lille score:

    Lille model score = (exp(-R))/(1 + exp(-R)),

    where:

    • exp is a short for the exponent.
Łucja Zaborowska, MD, PhD candidate
Age
years
PT
sec
Creatinine
mg/dL
Albumin
g/L
Bilirubin (day 0)
μmol/L
Bilirubin (day 7)
μmol/L
Results
Total score:
points
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