Carboplatin Calculator
This carboplatin calculator (carboplatin dose calculator) estimates your total carboplatin dose (in mg) using the creatinine clearance calculations (found using the ), and the targeted carboplatin AUC value.
). The evaluations are based on a person'sWe try our best to make our Omni Calculators as precise and reliable as possible. However, this tool can never replace professional medical advice.
Carboplatin dose  Calvert formula
Carboplatin is a chemotherapy medication used to treat some forms of cancer (e.g., lung, ovarian, or brain cancer). It is administered via injection into a vein. After 24 hours, 70% of this drug is excreted unchanged in the urine. Therefore, the dose depends on the function of the kidneys. We use the following Calvert formula to calculate kidney function:
Carboplatin dose (mg) = AUC × (GFR + 25)
where:

AUC
 the Area Under the Curve for carboplatin; and 
GRF
 Glomerular Filtration Rate (see: GFR calculator.).
❗ Remember about the maximum recommended carboplatin dose. Check the paragraph below for more details and a proper equation.
What is the maximum recommended carboplatin dose?
The maximum recommended carboplatin dose is calculated with a GFR estimate capped to 125 ml/min for patients with normal renal function. To compute the maximum dose your patient can receive, use the equation:
Maximum carboplatin dose (mg) = AUC × (125 ml/min + 25)
Maximum carboplatin dose (mg) = AUC × 150
As you can see, the maximum dose depends mostly on the target AUC.
Carpolatin AUC  What is AUC?
Area under the curve (AUC) is a term that frequently used in pharmacokinetics. It describes the variation of a drug's concentration in the blood's plasma as a function of time. In practice, the trapezoidal rule is used to estimate AUC, and the drug's concentration is measured at certain discrete points in time.
Target carboplatin AUC values of 5 and 7 mg/ml/min are recommended.
This carboplatin AUC calculator uses the above method to find your carboplatin dose.
How to use the carboplatin calculator? (carbo calculator)
Our carboplatin calculator computes the carboplatin dose in two steps:
 Calculating GFR using the CockcroftGault equation:
MEN: GFR = ((140  A) × W / (72 × Cr)
WOMEN: GFR = 0.85 × GFR formula for men
where:
`GRF` Glomerular Filtration Rate
`A`  age (years)
`W`  weight (kg)
`Cr`  serum creatinine (mg/dL)
Let's have a look at the example below:
We want to find the GFR of a 50 year old man who weighs 78 kilograms, and has a serum creatinine level of 1.2 mg/dL.
GFR = ((140  50) × 78 / (72 × 1.2)
GFR = (90 × 78) / (72 × 1.2)
GFR = (90 × 78) / (72 × 1.2)
GFR = 7020 / 86.4
GFR = 7020 / 86.4
GFR = 81.25 ml/min

 Once we have found GFR, we can use the Calvert formula (described above) to calculate the optimal carboplatin dose for the patient.
Example (continued):
Knowing the GFR of a patient and using the target AUC value of 6 mg/ml/min, we can calculate carboplatin dose for the patient.
Carboplatin dose (mg) = AUC × (GFR + 25)
Carboplatin dose (mg) = 7 × (81.25 + 25)
Carboplatin dose (mg) = 7 × 106.25
Carboplatin dose (mg) = 743.8
Our carbo calculator allows you to make all of the above calculations in seconds!
Additional considerations:

If your patient is overweight or obese (calculated BMI ≥ 25 kg/m²), consider using adjusting body weight for your carboplatin dose calculator.
adjusted BW [kg] = (IBW) + 0.4 × (CBW – IBW)
where
IBW
stands for ideal body weight, andCBW
stands for current weight. 
If your patient has low serum creatinine levels, consider using a minimum creatinine level of 0.7 mg/dL to avoid an overestimation of GFR.

Consider using EDTA or 24hour urine to measure creatinine clearance (not a mathematical equation) when dosing at an AUC > 6, or when using an uncapped creatinine clearance.