Sex
Male
Age
years
Weight
lb
Serum creatinine
mg/dL
Target AUC
mg/ml/min
Results
GFR
ml/min
Carboplatin dose
mg

This carboplatin calculator (carboplatin dose calculator) estimates your total carboplatin dose (in mg) using the Calvert formula). The calculations are based on a person's estimated creatinine clearance level (found using the Cockcroft - Gault equation), and the targeted carboplatin AUC value.

We try our best to make our Omni Calculators as precise and reliable as possible. However, this tool can never replace professional medical advice.

Carboplatin dose - Calvert formula

Carboplatin is a chemotherapy medication used to treat some forms of cancer (e.g., lung, ovarian, or brain cancer). It is administered via injection into a vein. After 24 hours, 70% of this drug is excreted unchanged in the urine. Therefore, the dose depends on the function of the kidneys. We use the following Calvert formula to calculate kidney function:

Carboplatin dose (mg) = AUC * (GFR + 25)

where:

Carpolatin AUC - What is AUC?

Area under the curve (AUC) is a term that frequently used in pharmacokinetics. It describes the variation of a drug's concentration in the blood's plasma as a function of time. In practice, the trapezoidal rule is used to estimate AUC, and the drug's concentration is measured at certain discrete points in time.

AUC describes the variation of a drug concentration in blood plasma as a function of time.

Target carboplatin AUC values of 5 and 7 mg/ml/min are recommended.

This carboplatin AUC calculator uses the above method to find your carboplatin dose.

How to use the carboplatin calculator? (carbo calculator)

Our carboplatin calculator computes the carboplatin dose in two steps:

  1. Calculating GFR using the Cockcroft-Gault equation:

MEN: GFR = ((140 - A) * W / (72 * Cr)

WOMEN: GFR = 0.85 * GFR formula for men

where:

`GRF`- Glomerular Filtration Rate

`A` - age (years)

`W` - weight (kg)

`Cr` - serum creatinine (mg/dL)

Let's have a look at the example below:

We want to find the GFR of a 50 year old man who weighs 78 kilograms, and has a serum creatinine level of 1.2 mg/dL.

GFR = ((140 - 50) * 78 / (72 * 1.2)

GFR = (90 * 78) / (72 * 1.2)

GFR = (90 * 78) / (72 * 1.2)

GFR = 7020 / 86.4

GFR = 7020 / 86.4

GFR = 81.25 ml/min

  1. Once we have found GFR, we can use the Calvert formula (described above) to calculate the optimal carboplatin dose for the patient.

Example (continued):

Knowing the GFR of a patient and using the target AUC value of 6 mg/ml/min, we can calculate carboplatin dose for the patient.

Carboplatin dose (mg) = AUC * (GFR + 25)

Carboplatin dose (mg) = 7 * (81.25 + 25)

Carboplatin dose (mg) = 7 * 106.25

Carboplatin dose (mg) = 743.8

Our carbo calculator allows you to make all of the above calculations in seconds!

Additional considerations:

  • If your patient is overweight or obese (BMI ≥ 25 kg/m²), consider using adjusting body weight for your carboplatin dose calculator.

    adjusted BW [kg] = (IBW) + 0.4 * (CBW – IBW)

    where IBW stands for ideal body weight, and CBW stands for current weight.

  • If your patient has low serum creatinine levels, consider using a minimum creatinine level of 0.7 mg/dL to avoid an overestimation of GFR.

  • Consider using EDTA or 24-hour urine to measure creatinine clearance (not a mathematical equation) when dosing at an AUC > 6, or when using an un-capped creatinine clearance.